Buccal delivery is considered to be an important alternative to the peroral route for the systemic administration of drugs, as it considered the most convenient, easy, safest route of administration. Sublingual films are intended for the application in the oral cavity beneath the tongue, drug absorbs totally through sublingual artery and entered in to systemic circulation. So, they are an innovative and promising dosage form especially for use in paediatrics and geriatrics. Olanzapine was selected as the active drug as it has low solubility and it is indicated in to schizophrenia where an immediate relief is always needed. Moreover sublingual film dosage form is very convenient for geriatric patient and those who have difficulty in swallowing tablets or in situations where access to water is not possible.\r\n Films were prepared according to the literature survey with a pre evaluation of different film formers such as, HPMC E-15, PVP, in combination with PVA by solvent casting method. PEG-400 is used as plasticizer. The prepared films, based on different formulations, were evaluated with regard to their morphology, mechanical properties and % Drug release. A 32 full factorial design was used to optimize the film. Compatibility studies with IR showed that drug is compatible with all the polymers and other additives. HPMC E-15 was found to be a good film forming agent. PVP and PVA were selected as factors in formulation; while % Drug release was studied up to 5 min. Formulation F1 was found to be the optimized among all nine batches with 100.91% release. Increase in the levels of PVA causes an increase in the Folding Endurance and % elongation. Surface pH of all the formulation is measured and all found in acceptable pH range. DSC spectra of film show that drug is totally embedded within polymer matrix, so stability of drug is also increased in formulation. Stability study results shows that formulation is stable over a period of 90 days at accelerated stability conditions.
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